Novel synthesis of long-circulating hpma copolymer - adriamycin conjugates

摘要

Molecular weight of a drug carrier conjugate is crucial for its effective functioning. Carriers with a molecular weight below the renal threshold are rapidly lost from the circulation. We have proposed previously to connect N-(2-hydroxy-propyl)methacrylamide (HPMA) chains via oligopeptide sequences into water soluble branched conjugates via oligopeptide sequences.