Thyroid cancer cells boundary location by a fuzzy edge detectionmethod

摘要

Morphometric assessment of tumor cells is important in theprediction of biological behavior of thyroid cancer. In order toautomate the process, the computer-based system has to recognize theboundary of the cells. Many methods for the boundary detection haveappeared in the literature and some of them applied to microscopic sliceanalysis. However, there is no reliable method since the gray-levels inthe nuclei are uneven and are similar to the background. In the paper, afuzzy edge detection method is used and is based on an improvedgeneralized fuzzy operator. The method enhances the nuclei andeffectively separates the cells from the background