Treatment of skin melanomas with the use of pulsed laser radiation

摘要

Abstract: The strong pulsed lasers radiation on the Neodim glass was used for the treatment of 265 patients with stage I skin melanoma. To 230 (86.4%) of them the treatment was carried out 5 years ago and even earlier. The duration of follow-up was from 1 to 22 years. The local recurrence of melanoma was diagnosed in 2 (0.75%) of these patients. Regional metastases developed in 44 (16.6%) patients, distant metastases - in 12 (4.5%) patients; in 1 (0.4%) patient the transport metastasis was revealed. More over, in patients to whom this type of treatment was carried out 5 years ago and even earlier regional metastases were diagnosed in 19.1% of cases, distant metastases - in 5.2% of cases, and transport metastases - in 0.4% of cases. 5-year survival rate of the patients made up 83.2%. In case of the I level of invasion (according to Clark classification) 100% of patients were alive for 5 years and even longer, in case of the II level of invasion this index made up 92.3%, in case of the III level - 85.7%, and in case of the IV level - 80.5%. In melanomas the thickness of which did not exceed 1.5 mm (according to Breslow classification) 5- year survival rate of the patients made up 96.7%, and in the tumors being from 1.51 mm to 4.5 mm thick this index mae up 80.0%. The strong pulsed lasers radiation is the effective method of treatment of plane or slightly elevated skin melanomas of the I-IV levels of invasion (Clark classification) the thickness of which is up to 4.5 mm according to Breslow.!10