Tissue distribution of liposomal zinc(II)-phthalocyanine in normolipaemic and hyperlipaemic rats following intravenous administration

摘要

Abstract: Liposomal formulations of the photosensitizer zinc(II)-phthalocyanine (Zn-Pc) readily interact with plasma lipoproteins in vitro and in vivo, leading to a redistribution of the photosensitizer amongst the major lipoprotein classes. As lipoprotein binding may facilitate the uptake of lipophilic photosensitizers by proliferating tissues, we have examined the fate of intravenously administered liposomal Zn-Pc in normolipaemic rats and rats rendered hyperlipaemic through dietary intervention. Differences were found in the plasma decay profiles of Zn-Pc and liposomal phospholipid between the two groups of animals. !15