Mechanism of photodynamic therapy (PDT): investigation of sensitizer dose and light dose-rate effects

摘要

Abstract: The thresholds in sensitizer concentration and in light dose rate for PDT effects have been examined on the basis of a chemical reaction. The examination revealed that there exists basically no thresholds of drug and light dose-rate effects in PDT, but apparently there does. Also it was suggested that PDT effects depend largely on peak power of laser and not so largely on the total joule. And for PDT the use of pulse laser with relatively high peak power is better than the use of the lower one, especially cw laser. !8