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Numerical modelling of temperature increase induced by transcutaneous Spinal Direct Current Stimulation (tsDC)

机译:经皮脊柱直流电刺激(tsDC)引起的温度升高的数值模型

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Transcutaneous spinal direct current stimulation is a well-tolerate biomedical technique used to modulate the activity of spinal nervous system. In the perspective to broad its use for better treating spinal injuries, new clinical protocols with higher current intensities are likely to be adopted. However, these can be introduced without a previous assessment of safety, which is not yet investigated for the current 3 mA stimulation. Safety of this technique is mainly associated to the temperature increase due to Joule heating not only in the spinal cord and nerves but also in the skin and in the possibly more vulnerable organs. In this study, temperature increase induced in these organs of different human body models is assessed through a computational approach which solves Laplace equation followed by Bioheat equation. Results show very low heating in all the tissues and body models considered and therefore suggest to exclude the role of Joule heating in the few side effects that current protocols have shown.
机译:经皮脊柱直流电刺激是一种耐受良好的生物医学技术,用于调节脊柱神经系统的活动。从扩大其在更好地治疗脊椎损伤中的用途的角度来看,可能会采用具有更高电流强度的新临床方案。但是,可以在不事先进行安全性评估的情况下引入这些功能,目前尚未针对当前的3 mA刺激进行调查。该技术的安全性主要与焦耳加热引起的温度升高有关,不仅在脊髓和神经中,而且还在皮肤和可能更脆弱的器官中。在这项研究中,通过计算方法来评估在不同人体模型的这些器官中引起的温度升高,该方法先求解Laplace方程,然后求解Bioheat方程。结果表明,在所考虑的所有组织和人体模型中,发热极低,因此建议排除焦耳热在当前方案显示的少数副作用中的作用。

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