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Reconstruction of Network Evolutionary History from Extant Network Topology and Duplication History

机译:远销网络拓扑和重复历史的网络进化史的重建

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Genome-wide protein-protein interaction (PPI) data are readily available thanks to recent breakthroughs in biotechnology. However, PPI networks of extant organisms are only snapshots of the network evolution. How to infer the whole evolution history becomes a challenging problem in computational biology. In this paper, we present a likelihood-based approach to inferring network evolution history from the topology of PPI networks and the duplication relationship among the paralogs. Simulations show that our approach outperforms the existing ones in terms of the accuracy of reconstruction. Moreover, the growth parameters of several real PPI networks estimated by our method are more consistent with the ones predicted in literature.
机译:由于最近生物技术的突破,基因组含蛋白 - 蛋白质相互作用(PPI)数据很容易提供。然而,产卵生物的PPI网络仅是网络演进的快照。如何推断整个演化历史成为计算生物学中有挑战性的问题。在本文中,我们介绍了一种基于可能的方法来推断从PPI网络拓扑的推断网络演变历史以及帕拉戈尔科之间的重复关系。模拟表明,在重建的准确性方面,我们的方法优于现有的。此外,我们的方法估计的几个真实PPI网络的生长参数与文献中预测的那些更符合。

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