Extracellular matrix derived from chondrocytes promotes rapid expansion of human primary chondrocytes in vitro with reduced dedifferentiation

摘要

Cell-type specific ECM contains unique biophysical and biochemical singals. This is the first report on modulating chondrocyte expansion and dedifferentiation using cell-type specific ECM. ECM derived from allogenic human chondrocytes (AC-ECM) supports a rapid expansion and reduced dedifferentiation of HAC. AC-ECM has the potential to be a preferred substrate for in vitro expansion of HAC cell-based therapies.