Bacteriophage Delivering Hydrogels Reduce Biofilm Formation In Vitro and Infection In Vivo

摘要

The results demonstrate that Paer14 has no negative impact on the viability of hMSCs, and that encapsulating Paer14 in PEG hydrogels significantly reduces the ability of PsAer-9 to colonize the surface of the gel. Furthermore, Paer14-delivering hydrogels significantly reduce infection in bone defects. This shows bacteriophage, such as Paer14, are a viable candidate for further investigation as potential antimicrobial agents in biomaterials implants.