Bacteriophage Delivering Hydrogels Reduce Biofilm Formation In Vitro and Infection In Vivo

摘要

The results demonstrate that ?Paer14 has no negative impact on the viability of hMSCs, and that encapsulating ?Paer14 in PEG hydrogels significantly reduces the ability of PsAer-9 to colonize the surface of the gel. Furthermore, ?Paer14-delivering hydrogels significantly reduce infection in bone defects. This shows bacteriophage, such as ?Paer14, are a viable candidate for further investigation as potential antimicrobial agents in biomaterials implants.