Biodegradable, Elastic Polyurethane with Enhanced Anti-Thrombogenicity as Blood-Contacting Biomaterials

摘要

A family of biodegradable, elastic and crosslinked polyurethanes with anti-thrombogenic drug was synthesized using a simple one step/one pot method. The crosslinked polyurethanes had good elasticity, and their mechanical and degradation properties can be tuned by altering the feeding ratio of DPA to PCL segments. The resultant anti-thrombogenic polyurethanes significantly reduced the platelet deposition on polymer surfaces before and after enzymatic degradation, and also supported the growth of HUVECs. These promising characters of the anti-thrombogenic and biodegradable elastomer show its great potential to be used as a blood contacting biomaterial.