Hemodynamics Analysis of Patients With Mild Cognitive Impairment During Working Memory Tasks

摘要

Diagnosis of dementia in early stage is important to prevent progression of dementia in the aging society. Mild cognitive impairment (MCI) denotes an early stage of Alzheimer disease (AD). In this paper, we aim to classify MCI patients from healthy controls (HC) during working memory tasks using functional near-infrared spectroscopy (fNIRS). To achieve this objective, t-values and correlation coefficients are calculated to find the region of interest (ROI) channels and brain connectivity. From the ROI channels averaged over subjects, features (mean and slope) of hemodynamic responses were extracted for classification. Extracted features were labelled as two classes and classified via two classifiers, linear discriminant analysis (LDA) and support vector machine (SVM). The classification accuracies were 73.08 % with LDA and 71.15 % with SVM. The results show that there are significant differences in the hemodynamic responses (HR) between MCI patients and healthy controls. Therefore, these results suggest a possibility of using fNIRS as a diagnostic tool for MCI patients.