The requirements for batch versus continuous processing are compared along the lines of the design attributes of single use sensors for pressure, temperature, conductivity. UV absorbance and a new low low sensor and also performance over months of continuous operation. These sensors are applicable in both upstream and downstream processing starting with monitoring on single use bioreactors, sensors required for perfusion process monitoring followed by monitoring of continuous purification processes. Points of consideration are the materials used and their durability for extended use beyond a batch process, availability of sensors for low flow rates often used in continuous processes performance in terms of a sensor remaining in calibration over an extended run. Finally, during continuous processing, it is often imperative that a process can be continuously controlled and data can be logged and trended 24,7. Therefore, interface of the sensors to higher level contral systems and to data historians is important and options will be examined to accomplish this for different plant architectures.
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