We have successfully attached the 2,3-difluorinated zanamivir analogs to the polymer via "Click Chemistry". The polyvalent conjugate showed improved anti-influenza virus activity with IC_(50) value about 1000 fold better than that of the corresponding monomer. This glycopolymer even showed better inhibitory activity compared with Zanamivir. A cell based cytopathic effect (CPE) reduction assay of the synthesized glycopolymer will be studied for the further inhibition evaluation and we expect this kind of polyvalent conjugates will be further used as potent anti-influenza agents.
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