PAMAM Dendrimers for Improved Timolol Delivery

摘要

Conclusions: In this work we have developed a novel dendrimer based vehicle for the anti-glaucoma drug timolol. Direct coupling of the active group on timolol to a generation 3.0 PAMAM dendrimer was accomplished using a PEG spacer. The final product showed excellent cytotoxicity in vitro. Preliminary animal tests indicate that the drug retains bioactivity similar to timolol after grafting. Ongoing experiments are evaluating the corneal permeability and ocular disposition of this material. Future experiments will focus on further characterizing the PK/PD profile of this coupled drug.