Statement of Purpose: The treatment of diseases that occur brain or cancer is difficult because of the poor transfer of drugs into complex biological barriers. Specific types of cells such as monocytes or mesenchymal stem cells can naturally cross this barrier, and offer a possible mode of active transport into the target area. While our prior work has demonstrated the capability of loading materials into hydrogel coatings on cells, a complete coating on the cell surface will disrupt the interaction of cells with their environments. To address this issue, cell surface patches that partially cover cell surfaces might provide a superior approach for cell mediated therapeutic delivery. The goal of this study is to establish an efficient approach to generate polymer patches on cell surface via polyethylene (glycol) diacrylate (PEGDA) photolithographic polymerization.
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