Antimicrobial Peptide Kills Bacteria but Presents Low Toxicity toward Human Cells

摘要

Conclusions: A new synthetic peptide was demonstrated in vitro to have significantly higher antimicrobial properties along with significantly lower toxicity toward human osteoblasts and lung epithelial cells compared to conventional antibiotics. Such an antimicrobial peptide may lead to significant beneficial outcomes (e.g. reduced infection and improved healing) in treating implant associated infections, especially those induced by antibiotic resistant bacteria. In future studies, the antimicrobial and toxicity properties of this synthetic peptide may be evaluated in an open fracture rat infection model.