Quality Assurance and Quality Control of Portable Devices using a Standard Reference Material

摘要

Standard Reference Materials (SRMs) are homogeneous, well-characterized materials that are used to validate measurements and improve the quality of analytical data (www.nist.gov/srm). The National Institute of Standards and Technology (NIST) has a wide range of SRMs that have values assigned for clinically important analytes, legacy organic pollutants, and toxic metals in human matrices. Examples of some SRMs include organic contaminants in human serum, human milk, and human urine, lead in caprine blood, arsenic species in human urine, and toxic elements in human urine. These SRMs can serve as materials for quality control when developing methods on a portable devise. Currently NIST has looked at different sampling techniques, including dried blood spot cards (DBS), and different portable devises, including CardioChek and VetScan. SRM 1958 Organic Contaminants in Fortified Human Serum (Freeze-Dried), SRM 955c Toxic Metals in Caprine Blood, and a solution of 25-hydroxyvitamin D_3 were spotted onto DBS cards to test the feasibility of using DBS to screen for analytes of interest. SRM 1950 Metabolites in Frozen Human Plasma was used to assess the precision and accuracy of the CardioChek and VetScan devises for field research. Results indicate that precise and accurate measurements for many compounds can be made using both devises.