A Hybrid Evolutionary Algorithm for Protein Structure Prediction Using the Face-Centered Cubic Lattice Model

摘要

A hybrid combination between Differential Evolution (DE) and a local search procedure was used for the protein structure prediction problem. The Face-Centered Cubic lattice model was employed for the protein conformation representation. A Lamarckian combination between the global search of DE and the local search provides better results for obtaining protein conformations with minimal energy under the same number of fitness evaluations in comparison with DE alone. The results were validated with several benchmark protein sequences.