Biocorrosion protection and osseointegration acceleration of titanium dental implants using simulated body fluid

摘要

Ti and Ti alloys are important materials for medical dental applications. Today, titanium dental implants are one of the most common methods of treating edentulous. However, the installation of such implants should take into consideration that in a a long enough period of time can occur biocorrosion. Successful treatment results in the immediate and long-term period, must have adequate surface of the implant, which combines the properties of wettability and porosity, that can be obtained by precipitation of ultrafine hydroxyapatite (HA) from a supersaturated solution of simulated body fluid 5xSBF (Simulated Body Fluid) which will prevent corrosion. Aim optimize quality and quantity of osseointegration of dental titanium implants through surface modification by precipitation method of the nanocrystalline HA from 5xSBF supersaturated solution for protection against biological corrosion. Objective: study the morphology of various titanium billets surface, calcium phosphates degree deposition from5xSBF at various titanium implants with different surface morphology. Titanium implants were placed in a freshly prepared 5xSBF-solution at 1, 5, 30 days and incubated at 36.6 °C. Further, the test samples were removed from the solution and dried at 30 °C in a drying oven in the air. Electron microscopic studies of the samples showed that the crystal layer formed on the surface of titanium implants, a smooth transition from the implant surface into the bulk of the calcium phosphate without visible boundaries due to the growth plate and the spherical crystals of calcium phosphate (ultrafine carbonated HA). Using simulation body fluid in surgical stomatology clinic speeds up the process of integration of dental titanium implants into bone and prolong the period of their use. This method has been successfully applied in mare than 50 clinical cases of patients with edentulous. The observation period of more than two years, which is carried out check-ups and dental computer tomography, according to which patients with an adequate level of hygiene, and follow all recommendations, there was not a single case of pereimplantit and cervical resorption in the implant installed. Compared with the technology of the mechanical application of HA, this technology provides a sacrificial ultrafine HA does not hinder the growth of the bone interface, and superhydrophilic surface. Obtained surface allows to create protective layer against natural bio-corrosion of titanium implants, as well as to expand the indications for dental implantation and increase the integration of indicators in patients with impaired mineral metabolism caused by various factors. This work was supported by Moscow City Government with RFBR Ne 15-38-70047; RFBR Ne 15-08-99597, 16-53-00154 and with the financial support of the RF President Grant, project MK-8668.2016.8.