Radiation therapy is one of the main treatment modalities for cancer. The objective of radiation therapy is to eliminate all cancer cells by delivering a prescribed dose of radiation to the tumor volume while sparing at the same time the surrounding tissues. Intensity-modulated radiation therapy (IMRT) is a sophisticated technologically-driven type of radiation therapy where non-uniform radiation fields are used to irradiate the patient from different beam angle directions. Appropriate selection of beam irradiation directions - beam angle optimization (BAO) problem - enhance the quality of the treatment plan. The BAO problem is a very difficult global non-convex optimization problem for which there are few or none commercial solutions. Typically, the BAO procedure is driven by the outcome of the fluence map optimization (FMO) problem - the problem of calculating the most adequate radiation intensities. However, functions used for modeling the FMO problem have little clinical meaning. Typically, selection/validation of treatment plans is done considering a set of dosimetric measures. In this study, we propose a treatment plan global score, based on dosimetric criteria and its relative importance, as alternative plan's quality measure to drive the BAO procedure. For the clinical case of nasopharyngeal tumor, the use of a global score to drive the BAO procedure lead to higher quality treatment plans. For similar target coverage, an improved organ sparing was obtained.
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