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Automatic Prediction of Linguistic Decline in Writings of Subjects with Degenerative Dementia

机译:退行性痴呆症患者语言文字下降的自动预测

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Given the limited success of medication in reversing the effects of Alzheimer's and other dementias, a lot of the neuroscience research has been focused on early detection, in order to slow the progress of the disease through different interventions. We propose a Natural Language Processing approach applied to descriptive writing to attempt to discriminate decline due to normal aging from decline due to pre-dementia conditions. Within the context of a longitudinal study on Alzheimer's disease, we created a unique corpus of 201 descriptions of a control image written by subjects of the study. Our classifier, computing linguistic features, was able to discriminate normal from cognitively impaired patients to an accuracy of 86.1% using lexical and semantic irregularities found in their writing. This is a promising result towards elucidating the existence of a general pattern in linguistic deterioration caused by dementia that might be detectable from a subject's written descriptive language.
机译:鉴于药物在逆转阿尔茨海默氏症和其他痴呆症方面的作用有限,因此许多神经科学研究已集中在早期发现上,以通过不同的干预措施减慢疾病的进展。我们提议将自然语言处理方法应用于描述性写作,以试图将正常衰老导致的下降与痴呆前状况引起的下降区分开来。在有关阿尔茨海默氏病的纵向研究的背景下,我们创建了一个独特的语料库,包含201个由研究对象撰写的控制图像描述。我们的分类器通过计算语言特征,使用他们在写作中发现的词汇和语义不规范现象,将正常人群与认知障碍患者的准确度区分为86.1%。这对于阐明由痴呆症引起的语言退化的一般模式的存在是有希望的结果,该模式可以从受试者的书面描述性语言中检测到。

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