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Taguchi optimization of Surface Plasmon Resonance-Kretschmann biosensor using FDTD

机译:使用FDTD的表面等离子体共振 - Kretschmann生物传感器的Taguchi优化

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This paper reports on the optimization of full-width-at-half-maximum (FWHM) of the surface plasmon resonance (SPR) curve from a graphene-based SPR biosensor. The biosensor was designed in the Kretschmann configuration which is commonly known as the most effective technique for plasmon excitation using Lumerical's finite-difference-time-domain (FDTD) analysis. The performance of the SPR biosensor can be monitored by analysing the FWHM of the SPR curves where a smaller value is desired due to a narrower resonance peak which generally corresponds to a higher transmission power resulting in a more sensitive bio-detection. To optimise the biosensor's FWHM, Taguchi's L9 orthogonal array method was utilized involving four control factors at three level values using the objective function of Smaller-the-Better (STB) signal-to-noise ratio (SNR) characteristic. The results show that the FWHM improved to 1.1261°with best settings of A3B2C3D1. The Taguchi-optimized biosensor achieved 36.98% increase in sensitivity for urea detection.
机译:本文报告了从基于石墨烯的SPR生物传感器的表面等离子体共振(SPR)曲线的全宽半最大(FWHM)的优化。生物传感器设计在KROTSCHMANN配置中,通常称为使用Lummon的有限差分 - 时域(FDTD)分析的等离子体激发最有效的技术。可以通过分析由于较窄的共振峰值而期望的SPR曲线的FWHM来监测SPR生物传感器的性能,这通常对应于更高的传输功率导致更敏感的生物检测。为了优化生物传感器的FWHM,使用较小 - 更好(SNR)信噪比(SNR)特性的目标函数,使用Taguchi的L9正交阵列方法。结果表明,FWHM提高至1.1261°,最佳设置为A3B2C3D1。 TAGUCHI优化的生物传感器实现了尿素检测灵敏度的36.98%。

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