Dielectrophoresis: Characterization of Triple-Negative Breast Cancer using Clausius-Mossotti Factor

摘要

This paper describes a new possible application of dielectrophoresis (DEP) in breast cancer detection. Breast cancer is one of the most common cancer diseases in Malaysia which makes 17.7% of all cases reported between 2007 and 2011. This research aims to determine the dielectric properties of biophysical and biochemical of triple-negative breast cancer (TNBC). The manipulation of TNBC will be on the detection and enumeration based on polarization factor between permittivity and conductivity of TNBC and suspended medium. The results of analytical modelling prove that there are dynamic changes in the dielectric values, which are the permittivity and conductivity values between TNBC cell and medium when the frequency input value is changed. The findings offer a framework for anticipating TNBC dielectric detection response on the basis of structure-function relationship and suggest that dielectrophoresis lab-on-chip (DLOC) application for TNBC detection and enumeration should be widely used as a surface marker-independent method and provide high precision analysis in cancer progression and treatment effectiveness.