Numerical estimation of a 10 nanosecond pulse effects on non-uniformly distributed liposomes

摘要

Nano-systems, often used in biomedical applications for the treatment of a broad category of illnesses, represent one of the nanomedicine approaches recently proposed to target specific drugs only in the region where the disease has been developed. Recently the use of this technique has been proposed with electropulsation, hence taking advantage of the enhanced permeabilization of the cell membrane and simultaneously control the release of the encapsulated drug by the nano-system. In this work, we focus our attention on the study of liposomes nano-systems controlled by the nanosecond pulses electric fields through a microdosimetric approach. The aim is to analyse the electric field necessary to porate a non-uniform distribution of 400 nm liposomes. The work has been carried out by randomly placing 30 liposomes between two electrodes with the application of a 10 nano-second electric field pulse.