We confirmed the capacity of eSrtA to catalyze multiple cycles of rapid conjugation and removal of LPETG tagged biomolecules. Using a mouse model, we demonstrated that such a strategy could also be applicable in situ. These studies showed a potential as a rapid, orthogonal, and reversible surface chemistry approach to regenerate selective molecular constitutents in ordert to extend the lifetime of bioactive films in a manner akin to living systems. Regeneration of anti-thrombogenic bioactive films in vivo will be further investigated.
展开▼
