DNA complex release system by injectable auto-forming alginate gel including amorphous calcium phosphate

摘要

The alginate solution containing ACP and DNA complex inoculated around tumor in mice formed a soft gel soon. It was gradually degraded to release the DNA complex continuously. The degradation rate of the alginate gel could be controlled by amount of ACP. The slow releasing system prepared with GM-CSF gene-encoding plasm id showed high therapeutic effect in tumor-bearing mice. Such injectable auto-forming alginate gel seems to be promising as a sustained-gene expression device.