Bioresponsive hydrogel embedded dark-gold nanoswitch to sense and overcome cancer multidrug resistance

摘要

This is the first proof-of-concept showing that hydrogels doped with dark-gold nanobeacons can be used to reverse the resistance of tumor cells to a chemotherapeutic drug. The system provides on-demand presentation of an inhibitor based on local MDR activity. This approach can be used to reverse the resistance to many other chemotherapeutic drugs to treat other types of cancer.