DockStar: A Novel ILP Based Integrative Method for Structural Modelling of Multimolecular Protein Complexes (Extended Abstract)

摘要

Atomic resolution modelling of large multimolecular protein complexes is a key task in Structural Cell Biology. A single cell consists of hundreds of different functional complexes. To understand how these complexes operate and to develop strategies to modulate them for therapeutic purposes, we need to describe their 3D structure. However, high resolution experimental techniques, such as X-ray crystallography and NMR spectroscopy cannot handle very large complexes, whereas electron microscopy or mass spectrometry produce low resolution data . It is becoming clear that integration of data derived from a variety of bio-physical techniques at multiple levels of resolution is essential for the structural analysis of large complexes.