Comparison of APRI, FIB-4 and fibro test in prediction of fibrosis and cirrhosis in patients with hepatitis C

摘要

Aspartate aminotransferase platelet ratio index (APRI), Fibrosis-4 (FIB-4) and Fibro test are noninvasive methods to assess liver fibrosis. The objective of this study is to analyze the diagnostic performance of these tests for assessment of hepatic fibrosis and cirrhosis during hepatitis C infection. Data for comparison of significant fibrosis and cirrhosis was obtained through earlier studies where the degree of fibrosis and cirrhosis was measured in accordance with METAVIR and Ishak scoring system. 52 studies analyzing APRI, FIB-4 and Fibro test for various stages of fibrosis in hepatitis C patients were assessed. The area under the SROC curves of the APRI, FIB-4 and Fibro test to estimate fibrosis were 0.7736, 0.7163, and 0.8921 respectively while the areas under SROC curves of the APRI, FIB-4 and Fibro test to predict cirrhosis were 0.8244, 0.8167, and 0.9422, respectively. Fibro test is better than others in estimating both presence and absence of fibrosis and cirrhosis.