Synthesis of Single-Core Iron Oxide Nanoparticles as a Tracer for Magnetic Particle Imaging

摘要

Superparamagnetic single-core iron oxide nanoparticles coated with oleic acid have been synthesized via high temperature decomposition of iron-oleate precursor. The particle's core and hydrodynamic size distributions are characterized utilizing a variety of methods including Fluxgate Magnetorelaxometry (MRX) and Photon Cross-correlation Spectroscopy (PCCS). The harmonic spectra of mobile and immobile samples were measured using our homebuilt Magnetic Particle Spectrometer (MPS) whereby the suitability of the synthesized particles as a tracer for MPI is analyzed. Furthermore, the MPS spectra of the fabricated single-core nanoparticles are compared with the harmonic spectra of Resovist(Bayer Schering Pharma, Berlin) and Ocean NanoTech nanoparticles.