The Effect of Microwave Treatment on the Drug Release Property of Gelatin Microspheres

摘要

This study was to investigate the effect of microwave treatment on the swelling ratio of the gelatin, the diameter and drug release behavior of gelatin microspheres. The results can be applied to the drug delivery system, wound dressings and so on. In the experiment gelatin was mixed with D.I. water with the ratio of 3:10. The UV treatment active functional groups of gelatin, so that secondary interactions between the molecular chains form. Gelatin was exposed on 2.5GHz microwave with radiation dose of 0 ～ 5150J. In the study, the temperature of mixture was used to control the diameter of gelatin microspheres. The temperature is controlled at the range of 40°C～70°C. The diameter distribute at the range of 0.05mm～0.6mm. The diameter of microsphere increases with the increasing of temperature, and the distribution is dispersed. The effect of microwave on the swelling ratio and degradation rate of gelatin were investigated. Microwave treatment for short term would raise the swelling ratio to 25%. However, the swelling ratio and degradation rate would become low as the time of microwave treatment was over a critical value.