Research Development on Vanadium-Dependent Haloperoxidases in Marine Algae

摘要

The halogenated marine natural products encompass a very wide range of compounds which often have important biological activities or pharmacological properties. The haloperoxidases are thought to be involved in the biosynthesis of these natural products. A new kind of haloperoxidases that contain vanadium in the active site capable of catalyzing halogenation reactions of several substrates have been subsequently isolated from a variety of organisms, particularly in marine algae. Due to their highly chemical and thermal stability, the vanadium-dependent haloperoxidases (vHPOs) attracted more attention in the last few years. The paper mainly contemplates on the types, biological properties, and molecular structures of marine algae vHPOs as well as their biochemical function and potential industrial applications.