In situ Preparation and Characteristics of a New Water-Soluble Heme Iron Via Hemin-Arginate Coacervation

摘要

A new water-soluble heme iron (WSHI) was prepared and characterized. Crystalline hemin and L-arginate in molar proportions of 1:3 were mixed in a acetone solution (acetone: water = 100:10, V: V), stirred at 25 °C, for 12 h, and then centrifuged, washed with acetone, freeze-dried, referred to as WSHI. No clear differences in UV spectrum, IR spectrum between hemin-arginate and hemin was founded, while a notable distinct of thermal sensitivity occurred by differential thermal analysis (DTA), which partly explained dissolution elevation of hemin-arginate. Hemin-arginate is stable and no coagulate occurred in Carbonate solution, phosphate solution, or tea water, respectively. So, Hemin-arginate can be used as a new heme iron supplement in food additives, functional foods, and Pharmaceuticals.