Prolonged delivery of siRNA from cathodic electrodeposited chitosan/siRNA complex on titania nanotube array

摘要

Incorporation of siRNA and titanium is a tough problem because of the vulnerable siRNA that results in difficulty of immobilization and long term maintenance. Our study provided a convenient strategy based on the CED technique to deposit chitosan/siRNA on TNT surface. The deposited coating could maintain siRNA for over two weeks in neutral condition, which was pivotal to functionalize titanium in a prolonged fashion. The further study will concentrate on the cellular effect of the CED coating. Our method not only establishes the organized chitosan/siRNA coating on TNT, but can also be used in other conductors and charge polymers, for different purposes.