The Effects of Activated Non-Aggregated Platelets on Blood Plasma Coagulation

摘要

Thrombus induced by biomaterials is partially due to platelet-mediated reactions and partially due to coagulation of blood plasma itself. Both depend on the surface properties of implanted materials and characteristics of the blood flow. Much of what we know about the blood coagulation cascade involves blood-plasma coagulation in vitro using plasma that is depleted of platelets. This approach simplifies the blood coagulation problem, but the role of platelet, especially when activated; in contribution to blood coagulation is not clear. This study isolated activated non-aggregated platelets and measured the coagulation time of plasma in the presence of platelets with other activators to investigate the relative contribution of platelets and activators on coagulation.