Glycosylated polypeptide nanofibers as polyvalent lectin inhibitors with enzymatically-tunable binding specificity

摘要

Glycosylated peptides that self-assemble into a supramolecular structure provide polyvalent glycans. These polyvalent glycans bind to target lectins and inhibit their biological activity. Lectin-binding specificity of glycosylated nanofibers is easily varied via a generalizable chemoenzymatic synthesis approach. Together, these data suggest the therapeutic potential of glycosylated nanofibers as polyvalent lectin inhibitors with tunable binding specificity.