While the GS coatings did demonstrate efficacy in reducing osteomyelitis they were unable to fully eliminate the infection. This may have been due to the dosage, infection method, elution kinetics or other factors. Further study is required and in vitro investigation of elution characteristics is currently underway. The study was unable to demonstrate whether DOPS coatings are capable of enhancing allograft osseointegration. Only the uninfected control mice showed any osseointegration and there were only 5 mice in each uninfected treatment group, which made statistical significance difficult to achieve from the histological data. Further research with larger sample sizes will be necessary to determine whether DOPS coatings are potentially useful for enhancing allograft osseointegration.
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