The SELMA study, a longitudinal study following 2,000 mother-child pairs from early pregnancy over birth and up in school age

摘要

All pregnant women in the county of Vaermland, Sweden, were invited to attend the SELMA study at their first visit at an antenatal clinic in week 10 of the pregnancy. Almost 40% did accept to particulate and about 2,500 pregnant women were recruited in February 2010. In the beginning of 2011, 2,094 children have been born into the study. The study provides an extensive dataset including biological samples stored in a biobank (urine/serum from 1st trimester, cord blood, urine form the child at 2 and 12 months of age), environmental samples stored frozen (air and dust from the home the during pregnancy and infancy period), questionnaire data from eight times (2 times during pregnancy and at 2, 6,12,18, 48 and 72 months of age of the child), and access to data from the routinely made health examinations of the children at the County Council of Vaermland. The overall aim with the SELMA study is to examine the importance of prenatal exposure for endocrine disrupting chemicals (EDCs) for chronic diseases/disorder in offspring children. Four different health outcomes are focused on including (1) genital outcomes including anogenital distance (AGD) and puberty onset, (2) metabolic disorders including overweight and obesity, (3) immunological diseases including asthma and allergy, and (4) neurodevelopmental outcomes.We now have data on 1st trimester EDC metabolite exposure including phthalates (MEP, MBP, MBzP, MEHP, MEHHP, MEOHP, MECCP, 7OH-MMeOP, 7OXO-MMeOP, 7CX-MMeOP) and phenols (bisphenol A, troclosan) in urine and perfluorinated compounds (PFHxS, PFHpA, PFOA, PFOS, PFNA, PFDA, PFUnDA, PFDoDA) in serum for 2,356 women and we have thyroid hormones in cord blood for 1,516 births (T3, free T4, T4, TSH). We are now planning for an extensive health examination of the children at the age of 6 years to be started during 2014 for a period of 2 years.