Effect of urinary concentration of phthalates and bisphenol A metabolites n the atopic dermatitis symptoms of children in a child day care center

摘要

Background The aim of this study was to evaluate the association of urinary phthalate and bisphenol A concentration on the severity of atopic dermatitis symptoms in children. Methods From May 2009 through April 2010, we surveyed 38 children, between the ages of three and seven years, in a child day care center in Seoul metropolitan city. Each teacher recorded an atopic dermatitis diary, which is consisted of scores on daily pruritus index, daily activity schedule, and ten questions on indoor environment. Biological monitoring of urine from boys' stool collected twice a day, at 11:30 am and 4:00 pm, was conducted to assess the phthalate and bispheol A level of the children. We measured the urinary concentraions of mono-2-ethyl-5-oxohexyl phthalate (5-oxo-MEHP), mono-2-ethyl-5-hydroxyhexyl phthalate(5-OH-MEHP), mono-isobutyl phthalate (MnBP), Bispenol A. Presence of the atopic dermatitis symptom was analyzed using logistic regression analysis after controlling for the potential confounders. Results Most of the phthalate metabolite levels were higher in the morning urine in the afternoon. There was a seasonal variation and highest level of 5-OH-MEHP, MnBP, and bisphenol A was measured during summer. Manifestation of atopic dermatitis symptoms was associated with 1 μg/L increase of urinary level of MnBP (adjusted odds ratio =4.37, 95% CI: 1.35～14.17) and bisphenol A (aOR 2.09, 95% CI: 1.11～3.94). Conclusion It is suggested that phthalate and bisphenol A may be associated with aggravation of atopic dermatitis symptom.