Formaldehyde exposure and allergic disease: MOthers and Children's Environmental Health (MOCEH)

摘要

Background and aims: This study investigated the association between Formaldehyde exposureand allergic disease of infants for case-control studies based in a defined cohort. Methods : We collected the eligible data of 1,751 pregnant women who were enrolled in birth cohort of having allergic disease (asthma, allergic rhinitis, atopic dermatitis) at either 12 or 24 months. The control group does not have allergic disease in follow-up period. We measured HCHO through direct home visiting for 54 household infants (35 Case group of allergic disease and 19 control group). Results : The mean levels of indoor and personal HCHO were 23.1 μg/m~3 and ? μg/m~3,respectively. The mean concentration of indoor HCHO was higher in allergic disease group (31.99 μg/m~3) than in the control group (14.94 μg/m~3)(p＜0.05). Also, the mean concentration of personal HCHO in allergic disease group (54.04 μg/m~3) was higher than in the control group(40.22 μg/m~3)(p＜0.05). Personal HCHO exposure was significantly associated with an increased risk of allergic disease of infants adjusted for gender, family history and indoor TVOC concentration (Adjusted OR 1.06; 95% CI 1.00 to 1.13). Conclusion :HCHO exposure may contribute to develop allergic disease. Therefore, infant's parent should make an efforts to reduce the HCHO exposure of home environment. Acknowledgment: This study was supported by the National Institute of Environmental Research, Republic of Korea.