In utero and peripubertal exposures to endocrine disrupting compounds on weight status and fat distribution at 8-13 years

摘要

Background: Exposures to the endocrine disrupting compounds (EDCs) bisphenol A (BPA) and phthalates have been linked to measures of child weight status in cross-sectional studies, but these do not capture the formative effects of early life exposures on adolescent anthropometry. Aims: We examined the association ofin utero and peripubertal exposures to BPA and nine phthalate metabolites with measures of weight status and fat distribution at 8-13 years of age. Methods: Among a preliminary analysis of 108 of 250 mother-child pairs from Mexico City, we estimated the effect of In-transformed BPA and phthalates exposures from maternal third trimester and peripubertal urines on the continuous outcomes of weight, height, body mass index (BMI), and waist circumference (WC), adjusted for child's age, sex, maternal education, socioeconomic status, birth cohort, and specific gravity of urine. Analysis for tricep skinfolds (TSF) were stratified by sex and adjusted for child's age and specific gravity of urine. Reported preliminary coefficients retain a p-value＜0.20. Results: Peripubertal MEP concentrations were suggestively associated with BMI (β=0.44; 1 ng/mL increase in In-transformed peripubertal MEP exposure is associated with a 0.44 unit increase in age-and-sex adjusted BMI), WC (β=1.21), weight (β=1.23), and TSF (β=0.53) while MCPP concentrations were negatively associated with BMI (β=-0.78) and WC (β=-1.87). Sex differences were found for females within utero exposures to MBP (β=-1.03) and MBzP (β=-1.37) with TSF.In utero and peripubertal BPA exposures were not associated with measures of fat mass and distribution at 8-13 years. Conclusions: These intriguing preliminary results suggest that certain phthalate metabolites that may have effects on BMI and fat distribution in peripuberty, with differences by sex. These results, and the null findings for BPA exposure, necessitate further investigation in a larger sample size.