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Miniature Optofluidic Darkfield Microscope for Biosensing

机译:微型光流体暗场显微镜,用于生物传感

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摘要

Darkfield microscopy is an extremely sensitive imaging and sensing modality due to its very low background. Metal nanoparticles as small as 20nm can been detected by darkfield imaging setups. However, traditional darkfield microscopes are bulky and require special illumination condensers, which limits their application in point-of-care biosensing. In this paper, we present a miniaturized darkfield microscope based on liquid metallic on-chip condensers and imaging lenses. This microscope is fully compatible with PDMS microfluidics and can be attached to a smartphone camera to build a complete handheld biosensing system with very high sensitivity and low cost.
机译:暗场显微镜由于其极低的背景,是一种极其敏感的成像和传感模式。暗场成像装置可以检测到小至20nm的金属纳米颗粒。但是,传统的暗场显微镜体积庞大,并且需要特殊的照明聚光镜,这限制了它们在即时医疗生物传感中的应用。在本文中,我们提出了一种基于液态金属片上聚光镜和成像透镜的微型暗场显微镜。该显微镜与PDMS微流体完全兼容,可以连接到智能手机摄像头,以非常高的灵敏度和低成本构建完整的手持式生物传感系统。

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