ToxComp #x2214; In vitro-in vivo extrapolation system for drug proarrhythmic potency assessment

摘要

The project aims to develop the systems biology driven, modeling and simulation based, easy to use for non-modelers platform for the drugs proarrhythmic potency assessment at the population level. Platform realizes the in vitro-in vivo extrapolation approach thus the input data comes from the patch clamp in vitro ionic currents inhibition studies. Covariates describing variability in population include cardiomyocyte, heart and plasma physiological parameters which are correlated with basic demographic information (age, gender). Simulated output data includes action potential and ECG derivatives where APD50, APD90 and QTc are analyzed as the endpoints. System was implemented with use of the Java/JavaFX technology and is available both on line and off line and distributed under the GPLv3 license. Its main role include clinical trials optimization and waiving, helping with the go-no go decision making.