In vivo Performance of Combinations of Autograft, Demineralized Bone Matrix, and Tricalcium Phosphate in a Rabbit Femoral Defect Model

摘要

Combinations of autograft s (i.e., PBA), allografts (i.e., DBM), and a synthetic bone graft based on TCP appear to promote osteointegration. No adverse effects such as inflammatory reactions or osteolysis (e.g., bone resorption) in a rabbit femoral defect model were observed over the course of the study. Histology and histomorphometry revealed that the synthetic bone graft substitute promoted new bone formation comparable to that by the allograft. These data suggest that synthetic BGS has potential as an alternative to allografts, thus preventing complications associated with allografts, such as disease transmission.