Targeted delivery of nanoparticles to emphysematous lungs: Systemic versus local therapy

摘要

We have demonstrated a better and uniform damage of lungs using inhalation of elastase. We also showed specific targeting of damaged elastin networks in the lungs of elastase inhaled mice. These nanoparticles specifically stick to damaged elastin while sparing the healthy elastin in the aorta. Furthermore, we investigated the amount of nanoparticles that could be targeted using two different delivery routes. Based on this data, we intend to deliver drugs to mitigate inflammation and regenerate elastin in the lungs in a controlled fashion, for restoration of alveolar elastin fiber matrix.