Deep inspiration breath hold radiotherapy for locally advanced lung cancer: Comparison of different treatment techniques on target coverage, lung dose and treatment delivery time

摘要

Patients with locally advanced non-small cell lung cancer (NSCLC) treated with concomitant chemo-radia-tion have a poor survival of 10-15% after five years and a high risk of local progression [1]. After radiation therapy (RT) 30% of patients present with symptomatic radiation pneumonitis, associated with significant morbidity and 2% mortality [2]. Mean lung dose (MLD) and relative amount of lung volume receiving a radiation dose of 20 Gy or more (V20) are reported to correlate with radiation pneumonitis [2-5].