Synthesis and Characterization of Lipid Nanoparticle Formulation of a Poorly Soluble, Highly Potent, Novel Synthetic Analog of Curcumin for Cancer Therapy

摘要

We have optimized lipid nanoparticle formulation which increases the solubility of the curcumin analog, Cl and has similar IC_(50) profile as the parent drug. These lipid nanoparticles are PEGylated and thus are expected to have higher half-life in blood circulation. In vivo efficacy and PK studies are currently underway.