Lipid-Coated Mesoporous Silica Nanoparticles for Antiviral Delivery to Inhibit Encephalitic Alphavirus Infection

摘要

In this work, we highlight the use ot an LC-MSNs technology for loading and release of antiviral ML336 to inhibit a vaccine strain of the VEEV virus. This technology is particularly versatile, and in the future, we intend to improve controlled release through surface modification of the MSN. In addition, we will functionalize lipids with targeting moieties for cell type-specific delivery. The LC-MSNs are also biocompatible and can have long circulation times, which will allow assessment of ML336-loaded LC-MSNs to inhibit virus in an animal model. As a whole, LC-MSNs have the potential to enable delivery of small molecule antivirals, reducing threats from naturally spreading viruses and bioterrorism. This work was funded by the Defense Threat Reduction Agency (DTRA), project 1002720595.