Immobilization of BMP-2 within a Poly(Ethylene Glycol) Hydrogel to Induce Osteogenesis in Serum-Free Conditions

摘要

BMP-2 was necessary to induce osteogenesis of MSCs in the photoclick hydrogels in defined medium. A simple bioconjugation strategy to thiolate BMP-2 maintains biological activity and can be tethered into the PEG network. Current work is investigating the effects of tethered BMP-2 on osteogenesis of encapsulated MSCs through biochemical assays, immuno-histochemical staining, and gene expression.